Meta-analysis of association between TPH2 single nucleotide poiymorphism and depression.

Tryptophan hydroxylase 2 (TPH2) plays a crucial role in the human brain. Although the association between the TPH2 gene and depression has been suggested in previous meta-analyses, studies based on Chinese subjects are often neglected. Therefore, we included some previous studies based on Chinese subjects to explore the relationship between TPH2 polymorphisms and depression via conducting an extensive meta-analysis. We reviewed 40 research papers that included data on TPH2 gene single nucleotide polymorphisms (SNPs) from 5766 patients with depression and 5988 healthy subjects. The analysis showed an association between polymorphisms in the TPH2 gene and depression, and some results were significant in 24 studies that included Chinese Han study participants. The results of our meta-analysis showed that rs4570625, rs17110747, rs120074175, rs4290270, rs120074175, and rs4290270 may be significantly associated with depression, and that rs11178997 (A/A genotype) may be a significant risk factor for depression in the Chinese subjects. Based on the results of this study, biological experiments should be performed in the future to explore how different SNPs affect depression.

Development and Validation of an Unethical Professional Behavior Tendencies Scale for Student Teachers.

Teacher's unethical professional behaviors affect students' physical and mental health. Prevention should start with student teachers, but empirical research is lacking in China. This study surveyed over 2,000 student teachers from China to examine the psychometric properties of a student teachers' unethical professional behavior tendencies scale which revised by primary and secondary school teachers' unethical professional behavior tendencies scale. Exploratory and confirmatory factor analysis confirmed that a bi-factor model fit the data best. The final student teachers' unethical professional behavior tendencies scale comprised four subscales, including a general factor (unethical professional behaviors) and four special factors (perfunctory attitude and carelessness, insults and discrimination, unfairness, and using power for personal gain). The student teachers' unethical professional behavior tendencies scale correlated negatively with their professional ethical values and positively with perceived frequency of unethical professional behaviors of college teachers around them. The data supported the scale's measurement invariance across gender, and male student teachers scored significantly higher on unethical professional behavior tendencies than female student teachers. The findings suggest that the student teachers' unethical professional behavior tendencies scale is a useful instrument for assessing student teachers' unethical professional behaviors in China.

The relationship between search for meaning in life and symptoms of depression and anxiety: Key roles of the presence of meaning in life and life events among Chinese adolescents.

BACKGROUND: Meaning in life has been associated with greater mental health. However, previous findings are inconsistent regarding how the search for meaning in life (SML) is related to mental health issues such as symptoms of depression and anxiety. This study proposed and tested a new model to explain how the relationship between SML and symptoms of depression as well as anxiety can be moderated by life events and mediated by the presence of meaning in life (PML). METHODS: Middle and high school students (N = 1,705, 836 girls and 869 boys; Mage = 14.37, SD = 1.70) were administrated the Meaning in Life Questionnaire, Adolescent Self-Rating Life Events Checklist, Center for Epidemiologic Studies Depression Scale, and the State Anxiety Inventory. RESULTS: Results showed that the relationship between SML and symptoms of depression (or anxiety) depended on the impact of the life events experienced by the individual. In general, SML served as a beneficial or unrelated factor for those experiencing low impactful life events, but as a harmful factor for those experiencing high impactful life events. For those experiencing middle impactful life events, SML had a positive direct effect, but a negative indirect effect (through PML) on symptoms of depression (or anxiety). LIMITATIONS: Data are cross-sectional, and the present study examined only middle school students, which may limit generalizability. CONCLUSIONS: The findings indicate a complex relationship between SML and mental health. Symptoms of depression, anxiety, and other related problems may be diminished by applying training programs and policies aimed at increasing PML and reducing negative life events.

Chinese college students' ability to recognize facial expressions based on their meaning-in-life profiles: An eye-tracking study.

OBJECTIVE: People can be categorized into one of four meaning-in-life profiles: High Presence High Search (HPHS), High Presence Low Search (HPLS), Low Presence High Search (LPHS), and Low Presence Low Search (LPLS).The main goal of this study is to provide a theoretical explanation for why Chinese people with different meaning-in-life profiles have different mental health levels than Western people, based on their emotional-cognitive-processing ability. METHOD: We adopted eye-movement analysis and recognition-judgment experimental paradigm concerning absolute-recognition judgment and relative-recognition judgment in our study. Moreover, we applied a multifactor and multilevel mixed-experimental design. We selected 118 participants for the experiments from the 788 Chinese college students who responded. RESULTS: Our results showed that HPHS individuals preferred positive-emotion pictures, LPLS individuals preferred negative-emotion pictures, HPLS individuals preferred positive- and neutral-emotion pictures, and LPHS individuals preferred neutral-emotion pictures. Moreover, HPHS individuals were better at accurately processing facial expression from pictures, while LPLS individuals lacked such ability. The fine-processing ability of HPLS and LPHS individuals was lower than that of HPHS yet higher than that of LPLS individuals. Moreover, the features of HPLS individuals were closer to HPHS, while those of LPHS individuals were closer to LPLS. CONCLUSIONS: Our findings support the hypothesis that meaning-in-life profiles have different immediate processing abilities and preferences regarding facial expression recognition and different emotional-cognitive-processing ability.

Affective and Cognitive Empathy in Pre-teachers With Strong or Weak Professional Identity: An ERP Study.

Pain empathy is influenced by a number of factors. However, few studies have examined the effects of strength of professional identity on pain empathy in pre-service teachers. This study used the event-related potential (ERP) technique, which offers a high temporal resolution, to investigate the neurocognitive mechanisms of pain empathy in pre-teachers with strong or weak professional identity. The N110 and P300 components have been shown to reflect an individual's emotional sharing and cognitive evaluation in pain empathy, respectively. The results of the current study show that pre-teachers with strong professional identity showed a significant difference in N110 amplitudes evoked towards painful and non-painful stimuli; whereas pre-teachers with weak professional identity did not show a significant difference in the amplitudes evoked by the two stimulus types. For the P300 component, pre-teachers with weak professional identity showed a significant difference in the amplitudes evoked towards painful and non-painful stimuli; whereas pre-teachers with strong professional identity did not show a significant difference in the amplitudes evoked by the two stimulus types. Our results indicate that pre-teachers with strong professional identity show a higher level of pain empathy than those with weak professional identity.